Easily excitable Neal Page (Steve Martin) is somewhat of a control freak. Trying to get home to Chicago to spend Thanksgiving with his wife (Laila Robins) and kids, his flight is rerouted to a distant city in Kansas because of a freak snowstorm, and his sanity begins to fray. Worse yet, he is forced to bunk up with talkative Del Griffith (John Candy), whom he finds extremely annoying. Together they must overcome the insanity of holiday travel to reach their intended destination.
Retired Special Forces soldier John Matrix (Arnold Schwarzenegger) lives with daughter Jenny (Alyssa Milano) in isolation, but his privacy is disturbed by former commander Franklin Kirby (James Olson), who warns him that his fellow soldiers are getting killed one by one. After Kirby leaves, Jenny is kidnapped by former Latin American dictator Arius (Dan Hedaya), who wants Matrix to restore him to power. Instead, Matrix sets out to take down the rogue leader and rescue his daughter.
When bratty 8-year-old Kevin McCallister (Macaulay Culkin) acts out the night before a family trip to Paris, his mother (Catherine O’Hara) makes him sleep in the attic. After the McCallisters mistakenly leave for the airport without Kevin, he awakens to an empty house and assumes his wish to have no family has come true. But his excitement sours when he realizes that two con men (Joe Pesci, Daniel Stern) plan to rob the McCallister residence and that he alone must protect the family home.