In 1977, college graduates Harry Burns (Billy Crystal) and Sally Albright (Meg Ryan) share a contentious car ride from Chicago to New York, during which they argue about whether men and women can ever truly be strictly platonic friends. Ten years later, Harry and Sally meet again at a bookstore, and in the company of their respective best friends, Jess (Bruno Kirby) and Marie (Carrie Fisher), attempt to stay friends without sex becoming an issue between them.
Seeking answers about the afterlife, Chicago medical student Nelson (Kiefer Sutherland) persuades his fellow pupils to help him end his life, and then resuscitate him in the nick of time. Atheist David (Kevin Bacon), playboy Joe (William Baldwin) and troubled Rachel (Julia Roberts) also journey into the unknown, looking for meaning in their own lives. As the experiments become more perilous, each is forced to contend with the paranormal consequences of trespassing on the other side.
As the holidays approach, Clark Griswold (Chevy Chase) wants to have a perfect family Christmas, so he pesters his wife, Ellen (Beverly D’Angelo), and children, as he tries to make sure everything is in line, including the tree and house decorations. However, things go awry quickly. His hick cousin, Eddie (Randy Quaid), and his family show up unplanned and start living in their camper on the Griswold property. Even worse, Clark’s employers renege on the holiday bonus he needs.
When bratty 8-year-old Kevin McCallister (Macaulay Culkin) acts out the night before a family trip to Paris, his mother (Catherine O’Hara) makes him sleep in the attic. After the McCallisters mistakenly leave for the airport without Kevin, he awakens to an empty house and assumes his wish to have no family has come true. But his excitement sours when he realizes that two con men (Joe Pesci, Daniel Stern) plan to rob the McCallister residence and that he alone must protect the family home.