Tired of the crime overrunning the streets of Boston, Irish Catholic twin brothers Conner (Sean Patrick Flanery) and Murphy (Norman Reedus) are inspired by their faith to cleanse their hometown of evil with their own brand of zealous vigilante justice. As they hunt down and kill one notorious gangster after another, they become controversial folk heroes in the community. But Paul Smecker (Willem Dafoe), an eccentric FBI agent, is fast closing in on their blood-soaked trail.
In early-1970s Las Vegas, low-level mobster Sam “Ace” Rothstein (Robert De Niro) gets tapped by his bosses to head the Tangiers Casino. At first, he’s a great success in the job, but over the years, problems with his loose-cannon enforcer Nicky Santoro (Joe Pesci), his ex-hustler wife Ginger (Sharon Stone), her con-artist ex Lester Diamond (James Woods) and a handful of corrupt politicians put Sam in ever-increasing danger. Martin Scorsese directs this adaptation of Nicholas Pileggi’s book.