Young lovers Walter (Tom Hanks) and Anna (Shelley Long) are house-sitting the New York City apartment owned by Max (Alexander Godunov), Anna’s ex-husband, who suddenly decides to toss them out. Needing a new home, they settle on buying a country estate outside the city, which is available for a suspiciously low price. It soon becomes apparent why, as doors fall off their hinges, staircases come tumbling down and a bathtub falls through the floor. The couple’s relationship suffers similarly.
In 1977, college graduates Harry Burns (Billy Crystal) and Sally Albright (Meg Ryan) share a contentious car ride from Chicago to New York, during which they argue about whether men and women can ever truly be strictly platonic friends. Ten years later, Harry and Sally meet again at a bookstore, and in the company of their respective best friends, Jess (Bruno Kirby) and Marie (Carrie Fisher), attempt to stay friends without sex becoming an issue between them.