In 1977, college graduates Harry Burns (Billy Crystal) and Sally Albright (Meg Ryan) share a contentious car ride from Chicago to New York, during which they argue about whether men and women can ever truly be strictly platonic friends. Ten years later, Harry and Sally meet again at a bookstore, and in the company of their respective best friends, Jess (Bruno Kirby) and Marie (Carrie Fisher), attempt to stay friends without sex becoming an issue between them.
When science whiz Mitch Taylor (Gabe Jarret) arrives at Pacific Tech as a freshman, he’s paired up with genius senior Chris Knight (Val Kilmer) to work on a laser project. Mitch initially doesn’t care for Knight’s slacker attitude, but is eventually won over, and their friendship allows them to make new progress on the laser project. It’s only when the boys learn that the government intends to use the laser as a weapon that they start to question what they’ve actually been working for.
A comic-book nerd and Elvis fanatic Clarence (Christian Slater) and a prostitute named Alabama (Patricia Arquette) fall in love. Clarence breaks the news to her pimp and ends up killing him. He grabs a suitcase of cocaine on his way out thinking it is Alabama’s clothing. The two hit the road for California hoping to sell the cocaine, but the mob is soon after them.
The Top Gun Naval Fighter Weapons School is where the best of the best train to refine their elite flying skills. When hotshot fighter pilot Maverick (Tom Cruise) is sent to the school, his reckless attitude and cocky demeanor put him at odds with the other pilots, especially the cool and collected Iceman (Val Kilmer). But Maverick isn’t only competing to be the top fighter pilot, he’s also fighting for the attention of his beautiful flight instructor, Charlotte Blackwood (Kelly McGillis).
Kat Stratford (Julia Stiles) is beautiful, smart and quite abrasive to most of her fellow teens, meaning that she doesn’t attract many boys. Unfortunately for her younger sister, Bianca (Larisa Oleynik), house rules say that she can’t date until Kat has a boyfriend, so strings are pulled to set the dour damsel up for a romance. Soon Kat crosses paths with handsome new arrival Patrick Verona (Heath Ledger). Will Kat let her guard down enough to fall for the effortlessly charming Patrick?
Teen misfits Gary (Anthony Michael Hall) and Wyatt (Ilan Mitchell-Smith) design their ideal woman on a computer, and a freak electrical accident brings her to life in the form of the lovely, superhuman Lisa (Kelly LeBrock). She outfits Gary and Wyatt in cool clothes, surprises them with a Porsche and helps them stand up to jerks Ian (Robert Downey Jr.) and Max (Robert Rusler). But, all the while, the boys must hide Lisa’s existence from Chet (Bill Paxton), Wyatt’s nightmare of a big brother.
After a wish turns 12-year-old Josh Baskin (David Moscow) into a 30-year-old man (Tom Hanks), he heads to New York City and gets a low-level job at MacMillen Toy Company. A chance encounter with the owner (Robert Loggia) of the company leads to a promotion testing new toys. Soon a fellow employee, Susan Lawrence (Elizabeth Perkins), takes a romantic interest in Josh. However, the pressure of living as an adult begins to overwhelm him, and he longs to return to his simple, former life as a boy.